The railroad first came to Canton in 1879.  The existing depot was built in 1907.  It was served by the Chicago, Milwaukee, St. Paul and Pacific Railroad.

The depot consisted of an Express Room, Cafe, Men and Ladies waiting rooms and a Ticket Office.  Records say that as many as 65 trains came in and out of Canton in a 24-hour period in its hey day.  The last passenger trains to come through Canton were in the 1960's.

The depot was moved to its current location in 1997 and renovations began on the building.  The Canton Chamber of Commerce moved its office into the south side of the depot in 2005. 

In 2007,  the Depot parking lot became the home of the Canton Farmers Market.  The Canton Farmers Market is open every Wednesday evening starting in June and continueing through October depending on the weather.

With the change in the Canton government from five commissioners to nine commissioners in November of 2007, the Canton City Commission began holding its meetings in the depot.